Curation: manual, uniform, documented
Predictions: pathway members, drug targets
Experiments: validate novel pathway members

      Features

      With SignaLink you can

• Biochemically defined pathways, all major developmental signaling mechanisms included
• Manual curation criteria & identical depth of detail for the entire database
• Multi-pathway proteins: proteins can belong to more than one pathway
• Proteins are classified by pathway position (core/non-core) and section (ligand, receptor, mediator, etc.)
• Interactions are directed and labeled with PubMed IDs of experimental evidence

• Browse signaling pathways, cross-talks and multi-pathway proteins
• Download species- and pathway-specific information in several formats
• Design genetic/biochemical experiments to
  verify predicted pathway member proteins
• Model tissue- or disease-specific signaling processes by merging SignaLink with expression data
• Discover novel signaling drug target candidates

Network view of the signaling pathways curated in SignaLink in human. Nodes (proteins) are coloured by the pathway section(s) (ligand, receptor, mediator, co-factor, and transcription factor) they belong to. Proteins that have no signaling interactions in SignaLink are shown separately on the left. Zoomable pathway images »

Comparing the four signaling pathways (EGF/MAPK, Notch, TGF, and WNT) curated in all four databases: Reactome, NetPath, KEGG, and SignaLink. Each section of the diagram shows the number of proteins in that set. The total number of proteins in the four pathways of each database is shown below the name of the database. For this figure only proteins listed in UniProt/Swiss-Prot were used (no TrEMBL proteins). Background image from R. Millard. Details »